无法手术的中晚期胰腺癌HIFU治疗后的生存分析

Survival analysis of unresectable advanced pancreatic cancer after high intensity focused ultrasound therapy

目的观察高强度聚焦超声(HIFU)治疗不能手术的中晚期胰腺癌的2年生存情况。方法对38例不能手术的中晚期胰腺癌患者进行HIFU治疗,记录术后肿瘤标志物、疼痛评分、生活质量评分的变化和生存情况。结果 HIFU治疗前有疼痛症状的35例患者,治疗后有28例患者疼痛症状有缓解(80.0%)。38例患者糖类抗原19-9(CA19-9)和癌胚抗原(CEA)较HIFU治疗前明显降低。影像学检查显示HIFU治疗区呈凝固性坏死表现,随访中肿瘤体积明显缩小。患者的中位生存期延长为(12.9±6.6)个月。结论 HIFU治疗能有效改善不能手术的胰腺癌患者生活质量,延长生存期。

Objective To observe the 2-year survival situation of high intensity focused ultrasound（HIFU） treatment in unr- esectable advanced pancreatic carcinoma. Methods Thirty-eight patients with unresectable pancreatic cancer received HIFU treat- ment. After treatment, the changes of laboratory tumor markers examination results, pain score,life quality score and survival situa- tion were recorded. Results Among 35 patients with pain symptom before HIFU treatment,pain was relieved after HIFU treat- ment in 28 cases, the remission rate was 80.0 %. The CA19-9 and CEA levels after HIFU therapy were obviously reduced compared with before treatment. The imaging examination showed the coagulation necrosis in HIFU-treated area. It was found the tumor vol- ume was obviously shrunk during follow-up period. The median survival period was extended to（12.9 ±6.6） months. Conclusion The HIFU treatment can effectively improve the life quality in the patients with unresectable pancreatic cancer and extends their survival period.