2型糖尿病患者血清正五聚蛋白3与代谢指标相关性的分析

Analysis on correlation between serum pentraxin 3 and metabolic indices in patients with type 2 diabetes mellitus

目的探讨血清正五聚蛋白(PTX)3水平在2型糖尿病(T2DM)患者不同体质量指数(BMI)组中的变化及与代谢指标的相关性。方法 164例T2DM患者根据BMI分为体质量正常组(A组)53例、超重组(B组)56例及肥胖组(C组)55例,采用酶联免疫法测定各组血清PTX3水平,分析血清PTX3水平与BMI、血糖、血脂、胰岛素抵抗指数(HOMA-IR)等的关系。结果血清PTX3水平在A、B、C组分别为(3.46±0.19)、(2.47±0.21)、(1.44±0.18)ng/mL,组间两两比较,差异有统计学意义(P<0.05)。PTX3水平与BMI、TG、LDL-C、空腹胰岛素(Fins)、HOMA-IR负相关(r分别为-0.897、-0.621、-0.232、-0.593、-0.487,P<0.01或P<0.05),多元逐步回归分析显示,BMI、HOMA-IR与PTX 3水平独立相关。结论 T2DM患者中,BMI、HOMA-IR是影响血清PTX 3水平降低的独立危险因素。

Objective To investigate the change of serum pentraxin3 level in different body mass indices groups among the patients with type 2 diabetes mellitus（T2DM） and to analyze its correlation With metabolic indices. Methods A total of 164 T2DM patients were divided into the normal body mass group （A, n= 53）, over-weight group （B, n = 56） and obese group（C, n = 55） ac- cording to BMI. Serum pentraxin3 level was assayed by ELISA. Then the relationship between serum pentraxin3 levels with BMI, blood glucose,blood lipid andHOMA-IR was analyzed. Results The pentraxin3 levels in the group A,B and C were （3.46±0.19）, （2.47 ± 0.21）, （1.44 ± 0. 18） ng/mL respectively, the pairwise comparison among three groups showed the statistical difference （P〈0.05）, The pentraxin3 level was negatively correlated with BMI, TG, LDL-C, FINS and HOMA-IR （r= - 0. 897, - 0. 621, - 0. 232, - 0. 593, - 0. 487, P〈 0.05 or P〈 0.01）. The multiple stepwise regression analysis showed that BMI and HOMA-IR were independently correlated with serum pentraxin31evel. Conclusion BMI and HOMA-IR are the independent risk factor for af- fecting serum pentraxin3 level in T2DM patients.