烟台和威海地区两医院健康人群年龄、性别、吸烟对血清总IgE水平的影响分析

The influence of gender,age,smoking on the levels of serum total IgE of healthy people in two hospitals in Yantai and Weihai areas

目的 通过对烟台、威海地区两医院健康人群血清总IgE水平的调查,分析影响血清总IgE水平的因素,为过敏性疾病的临床诊断提供信息.方法 采用化学发光法对1 200例健康人群及600例吸烟组血清总IgE水平进行检测.结果 各年龄段健康人血清总IgE含量分别为：≤6岁为（28.53±20.71）IU/mL,7~12岁为（29.74±25.94）IU/mL,13~18岁为（32±22.32）IU/mL,19~44岁为（45.2±36.27）IU/mL,45~60岁为（35.47±27.23）IU/mL,〉60岁为（31.2±25.03）IU/ml.≤6岁、7~12岁、13~18岁、45~60岁、〉60岁各组间差异无统计学意义（t=0.610、1.508、0.777、0.160、1.518,均P〉0.05）,19~44岁与其他年龄组差异有统计学意义（t=0.075,P〈0.01）.各年龄段总IgE水平性别差异无统计学意义（P〉0.05）.吸烟组血清总IgE含量分别为：19~44岁（55.22±39.16）IU/mL,45~60岁（42.63±28.46）IU/mL,〉60岁（39.32±26.73）IU/mL.吸烟组血清总IgE水平较同年龄组健康组明显升高,差异均有统计学意义（t=0.142、0.174、0.235,均P〈0.05）.结论 从出生到成年,总IgE水平差异并不明显,但到19~44岁年龄段,总IgE水平呈明显上升趋势,随后总IgE水平随着年龄的增长有所下降.男性与女性总IgE水平在不同年龄段均无显著差异.但是19岁以后,吸烟可使总IgE水平升高.

Objective To investigate serum total IgE levels of healthy population in two hospitals in Yantai and Weihai areas,to investigate the influencing factors of the levels of serum total IgE,which can provide information for the clinical diagnosis of allergic diseases.Methods The total serum IgE level was measured with chemiluminescence method in 1 200 cases of healthy people and 600 cases of smoking group in different age groups.Results The total IgE level of ≤6 years was （28.53±20.71）IU/mL,7-12 years was （29.74±25.94）IU/mL,13-18 years was （32±22.32）IU/mL,19-44 years was （45.2±36.27）IU/mL,45-60 years was （35.47±27.23）IU/mL,〉60 years was （31.2±25.03）IU/mL.There was no effect of serum total IgE in different age groups：≤6 years,7-12 years,13-18 years,45-60 years,〉60 years（t=0.610,1.508,0.777,0.160,1.518,all P〉0.05）,19-44 years was significantly different from other age groups（t=0.075,P〈0.01）.There was no gender difference of serum total IgE in different age groups （P〉0.05）.The total IgE level of the smoking group：19-44 years was （55.22±39.16）IU/mL,45-60 years was （42.63±28.46）IU/mL,〉60 years was （39.32±26.73）IU/mL.The level of serum IgE in the smoking group was significantly higher than that in the same age group （t=0.142,0.174,0.235,all P〈0.05）.Conclusion No significant difference existed in healthy people of serum total IgE levels from birth to adulthood.However,the total IgE level rose when reached to 19-44 years,which then slightly declined as the growth of the age.There was no significant difference between male and female of the IgE levels in different age groups.But after the age of 19,smoking can lead to the increase of the total IgE level.