翼状胬肉切除联合自体角膜缘干细胞移植术治疗原发性翼状胬肉50例疗效观察

Clinical observation of pterygium excision combined with autologous limbal stem cell transplantation in the treatment of 50 cases of primary pterygium

目的 观察翼状胬肉切除联合自体角膜缘干细胞移植术治疗原发性翼状胬肉患者的临床疗效.方法 选取原发性翼状胬肉患者50例（72只眼）,按照随机数字表法分为对照组（37只眼）行翼状胬肉切除术及研究组（35只眼）在此基础上联合自体角膜缘干细胞移植术治疗,两组各25例,并对比两组治疗效果.结果 研究组修复时间[（3.02±0.37）d]明显短于对照组[（6.85±0.48）d]（t=2.95,P=0.01）,复发率（20%）明显低于对照组（52%）（x2=10.35,P=0.03）,且术后并发症发生率（8%）亦明显低于对照组（36%）（x2=13.94,P=0.03）.结论 相比纯粹翼状胬肉切除术治疗,翼状胬肉切除联合自体角膜缘干细胞移植术治疗原发性翼状胬肉患者具有更高的临床疗效,能够有效缩短修复时间和降低复发率,且安全性较高,临床上值得进一步推广和应用.

Objective To observe the curative effects of pterygium excision combined with autologous limbal stem cell transplantation in the treatment of primary pterygium.Methods 50 cases （72 eyes） of primary pterygium were selected in our hospital.According to the method of random number table,50 canses were divided into the control group （37 eyes） underwent pterygium excision and the study group （35 eyes） received autologous limbal stem cell transplantation on the basis of the control group,with 25 cases in each,and the efficacy were compare between the two groups.Results The healing time of study group[（3.02±0.37）d] was significantly shorter than in the control group[（6.85±0.48）d]（t=2.95,P=0.01） and the recurrence rate （20%） was significantly lower than in the control group （52%） （x2=10.35,P=0.03）,and the postoperative complications rate （8%） was significantly lower than in the control group （36%） （x2=13.94,P=0.03）.Conclusion Compared with pure pterygium excision,pterygium excision combined with autologous limbal stem cell transplantation in the treatment of primary pterygium has higher clinical efficacy,which can effectively shorten the repair time and reduce recurrence rate,with high safety,so it is worthy of further promotion and application in clinic.