颅内动脉瘤扩张和破裂的危险因素及其干预的研究进展

Advances in Research of the Therapeutic Interventions for Dilation and Rupture of Intracranial Aneurysm

颅内动脉瘤的治疗方式主要包括保守治疗、开颅夹闭以及介入治疗,但许多微小动脉瘤并不适宜进行手术以及介入治疗,且在观察随访过程中存在发展和破裂的风险,因此有必要对颅内动脉瘤发展与破裂机制进行研究,探究控制颅内动脉瘤进展和破裂的靶点。文中就目前控制颅内动脉瘤发生、扩张、破裂的危险因素和干预的研究现状做一综述,对于颅内动脉瘤的预防与治疗进行回顾和展望。

The treatment of intracranial aneurysm included observation, craniotomy clipping and interventional therapy. But many micro-aneurysms do not fit the indications for surgery or interventional modality, and also they may develop or rupture during observation. So it is necessary to explore the interventions to control the progress and rupture of intracranial aneurysm. The biological interventions for dilation and rupture of intracranial aneurysm were summaried and the prospect for the therapy of intracranial aneurysm were reviewed.