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辛苯聚醇阴道用温敏凝胶的流变学特性及缓释滞留性研究 被引量:3

Rheological Properties and Retention Ability of Octoxynol-9 Vaginal Thermosensitive in Situ Gel
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摘要 目的:考察辛苯聚醇阴道用温敏凝胶[(O-9)-VTG]的流变学性质以预测其在体胶凝行为;评价其在阴道内的滞留性。方法:采用哈克旋转流变仪测定(O-9)-VTG在相变过程中及经阴道模拟液稀释后的流变学参数,考察其流变学性质。大鼠阴道给予自制(O-9)-VTG和O-9凝胶,分别测定阴道冲洗液中辛苯聚醇浓度,评价其滞留性。结果:(O-9)-VTG在室温条件下为黏弹性较低的牛顿流体,温度升至32.6℃时相变完成;且经阴道模拟液稀释后在体温条件下仍能形成凝胶。制备的(O-9)-VTG可在大鼠阴道滞留时间达8 h以上。结论:(O-9)-VTG具有适宜的胶凝温度和良好的流变学性质;与自制O-9凝胶相比,(O-9)-VTG具有显著的阴道黏附滞留性,能更好地满足阴道局部用药的要求。 Objective: To observe the rheological properties of octoxynol-9 vaginal thermosensitive in situ gel [ ( 0-9 ) -VTG ] for predicting the gelation behavior in vivo, and evaluate the retention ability in vagina. Methods : The rheological parameters of ( 0-9 ) - VTG and (O-9)-VTG diluted by stimulant vaginal fluid (SVF) were measured by a Haake Rheomix to characterize the rheological properties. The vaginal samples after the administration of self-made ( 0-9 ) -VTG and 0-9 gel were withdrawn, and then the concentra- tion of octoxynol-9 in the samples was determined to evaluate the retentionability. Results : (0-9) -VTG was Newtonian fluid with low viscoelasticity under room temperature and converted to gel at 32.6℃. The formula could still transform into gel at body temperature af- ter diluted by SVF, and resided in the vagina of mice above 8 h. Conclusion: (O-9) -VTG has suitable gelation temperature and rheo- logical properties. Compared with the self-made octoxynol-9 gel, (0-9)-VTG has satisfactory retention in vagina, which meets the re- auirements for vazinal topical use.
作者 袁萍 陈鹰 刘丽娜 Yuan Ping Chen Ying Liu Li' na(Department of Pharmacy, Wuhan General Hospital of PLA, Wuhan 430070, China School of Pharmaceutical Science, Hubei University of Chinese Medicine)
出处 《中国药师》 CAS 2017年第6期982-985,共4页 China Pharmacist
基金 湖北省卫生和计划生育委员会科研项目(编号:WJ2015MB115)
关键词 辛苯聚醇 温敏凝胶 流变学 缓释滞留 Octoxynol-9 Thermosensitive in situ gel Rheological properties Retention ability
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