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从胃排空调节及其影响药物谈2型糖尿病餐后血糖管理策略 被引量:7

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摘要 近年来,2型糖尿病(T2DM)成为全球重大公共健康问题.T2DM血糖管理需兼顾空腹血糖和餐后血糖的全面控制,使糖化血红蛋白(HbA1c)达标.降低餐后血糖对整体血糖控制非常重要,当HbA1c〈8.5%时,餐后血糖对HbA1c的贡献率超过50%[1].控制餐后血糖可通过不同机制实现,如延缓碳水化合物在肠道内的吸收,刺激胰岛素第一时相分泌等.随着新型降糖药物肠促胰素上市,胃排空对餐后血糖的调节作用引起了广泛关注.胃排空是食物由胃进入小肠的过程,葡萄糖在小肠内吸收入血,因此进食后血糖水平受胃排空速率影响,而胃排空速率受肠促胰素等多重神经激素调控.本文将就近年胃排空的研究进展及其与餐后血糖的关系予以综述.
出处 《中华糖尿病杂志》 CAS CSCD 2017年第5期334-336,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
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