信号转导和转录激活因子3与淋巴瘤关系及分子靶向治疗的研究进展

Research progress in signal transductions and activators of transcription 3 and molecular targeted therapy in lymphomas

信号转导和转录激活因子3(signal transductions and activators of transcription 3,STAT3)在各种细胞系与组织中广泛表达,参与细胞增殖、分化、衰老、凋亡等生理过程的调控。STAT3在多种肿瘤中高表达并持续激活,在肿瘤的发生发展中起关键作用。淋巴瘤是一类起源于淋巴造血系统的单克隆增殖性疾病,病理类型较为复杂,具有高度异质性,其发病机制尚未完全阐明。近年研究发现STAT3在各种类型淋巴瘤中异常表达,本文就STAT3的生物学作用、国内外关于STAT3与淋巴瘤关系以及分子靶向治疗的研究进展进行综述。阐明STAT3与淋巴瘤发生发展的关系,将为淋巴瘤的临床诊断和治疗提供更多思路。

Signal transductions and activators of transcription 3 （STAT3） is widely expressed in cell lines and tissues, and regulates cell proliferation, differentiation, senescence, apoptosis and other physiological process. STAT3 is overexpressed and continuously activated in a variety of tumors, suggesting it plays a critical role in tumorgenesis and progression. Lymphoma is a kind of malignant hyperplastic diseases with heterogeneity and complicated pathological classification, which is originated in lymphatic hematopoietic system. The pathogenesis oflymphoma has not been completely elucidated. Recently, it was reported that STAT3 is abnormally expressed in various subtypes of lymphomas. This article summarizes the research progress of the role of STAT3 and the molecular targeted therapy in lymphomas. We expect to provide more strategies for the diagnosis and treatment of lymphomas by illuminating the relationship between STAT3 and lymphomas.