PCT在上尿路结石继发尿脓毒血症中的临床研究

Clinical studies of procalcitonin for upper urinary calculi with urine sepsis

目的 研究降钙素原（PCT）在上尿路结石继发尿脓毒血症中的应用价值.方法 回顾性分析2014年1月至2016年6月在本院泌尿外科及重症医学科住院期间诊断为上尿路结石引起的尿脓毒血症患者资料45例.入院时根据尿脓毒血症诊断标准分为SIRS组及严重脓毒血症两组,比较两组性别、年龄、肾积水及PCT值,入院后根据手术处理方式分为同时处理梗阻与结石（Ⅰ期）与单纯处理梗阻（分期）两组,比较两组PCT值.结果 SIRS组及严重脓毒血症两组性别比较差异有统计学意义（P＜0.05）,两组入院时PCT值分别为（2.09±1.85）及（19.09 ±.25.15） ng/mL,组间比较有统计学意义（P＜0.05）;入院后在同时处理梗阻及结石（Ⅰ期）与单纯解除梗阻（分期）两组间术前24h PCT值比较差异分别为（0.2±0.24）及（20.04±27.08） ng/mL,组间比较有统计学意义（P＜0.05）.结论 PCT在评估患者感染程度及指导治疗方面具有较高临床价值.

Objectives To study the value of procalcitonin （PCT） for upper urinary calculi with urine sepsis.Methods A retrospective analysis was made on clinical data of 45 cases of upper urinary calculi with urine sepsis from January 2014 to June 2016 in our hospital.All patients were divided into urine sepsis SIRS group and severe sepsis group according to diagnostic criteria of urine sepsis.Gender,age,hydronephrosis and PCT values of the two groups were compared.The patients in the obstruction and stones （phase Ⅰ） group and simple processing obstruction （stage） group were treated after admission,and two groups of PCT values were compared.Results There was significant differencr between the two groups in the SIRS group and the severe sepsis group（P 〈0.05）,the PCT values of the patients in the two groups was （2.09 ± 1.85） and （19.09 ±25.15） ng/mL,there was significant difference between the two groups （P 〈 0.05）.The difference of 24 h PCT values between the two groups before and after treatment in the treatment of obstruction and calculi（stage Ⅰ） and the simply removal of obstruction （stage） was （0.2 ± 0.24） and （20.04 ± 27.08） ng/mL,there was significant difference between the two groups （P 〈 0.05）.Conclusions PCT has high clinical value in evaluating degree of infection and guiding the treatment of patients.