宫颈病变与不同年龄人乳头瘤病毒感染的相关性研究

Correlation of cervical lesions with HPV infection in patients of different age

目的分析宫颈病变与不同年龄人乳头瘤病毒(HPV)感染之间的相关性。方法选取北京市通州区新华医院自2013年6月至2015年6月就诊的620名患者为研究对象,经组织病理学确诊有不同宫颈病变186例,分析不同年龄HPV感染中宫颈病变患者的临床资料。结果 620例患者中HPV阳性172例(27.74%),其中包括HPV16阳性104例(16.77%),HPV18阳性27例(4.35%),HPV33阳性21例(3.39%),HPV31阳性13例(2.10%),HPV39阳性7例(1.13%)。31~40岁年龄段HPV感染率最高(33.92%),其次为41~50岁年龄段(27.27%)和21~30岁年龄段(24.67%),不同年龄段HPV感染率有显著性差异(χ~2=11.890,P<0.05)。620例患者中有不同宫颈病变186例,各宫颈病变中HPV感染率无显著性差异(χ~2=2.287,P>0.05)。41~50岁年龄段宫颈病变发生率最高(47.59%),其次为31~40岁年龄段(33.04%),再次为51~60岁年龄段(26.47%),经Fisher确切概率法检验,不同年龄段宫颈病变发生率有显著性差异(P<0.05)。结论宫颈病变与HPV感染有关,不同年龄段HPV感染率不同,宫颈病变发病率也不用,应针对高危年龄进行筛查。

Objective To explore and analyze the correlation of cervical lesions with human papillomavirus （HPV） infection at different ages.Methods From June 2013 to June 2015 totally 620 cases were selected in Beijing Tongzhou District Xinhua Hospital, and 186 cases were clinically diagnosed as suffering from varying degrees of cervical lesions.Clinical data of cases of cervical lesions among HPV infection at different age in the study were analyzed.Results Of 620 cases, HPV positive were found in 172 cases （27.74%）, including HPV16 positive in 104 cases （16.77%）, HPV18 positive in 27 cases （4.35%）, HPV33 positive in 21 cases （3.39%）, HPV31 positive in 13 cases （2.10%）, and positive HPV39 in 7 cases （1.13%）.Patients at 31-40 ages had highest rate of HPV infection （33.92%）, followed by those aged 41-50 years old （27.27%） and 21-30 years old （24.67%）.The HPV infection rate among patients of different age was significantly different （χ2=11.890, P〈0.05）.There were 186 patients with different cervical lesions, and no significant difference in the incidence of HPV infection was found （χ2=2.287, P〉0.05）.Patients aged 41-50 years old had highest incidence of cervical lesions （47.59%）, followed by those aged 31-40 years old （33.04%） and 51-60 years old （26.47%）.Fisher＇s exact probability method revealed that the difference in incidence of cervical lesions was remarkable at different age （P〈0.05）.Conclusion Cervical lesions are associated with HPV infection, and the incidence of HPV infection and cervical lesions is different at different ages.High-risk aged patients should be screened.