白介素1家族在脂肪肝疾病中的作用及机制研究进展

Research progress on role and mechanism of interleukin-1 in fatty liver diseases

白介素1(interleukin-1,IL-1)炎症因子家族在脂肪肝疾病进程中发挥关键作用。IL-1炎性因子家族参与脂肪肝疾病发生发展的各个阶段,如肝炎、肝纤维化、肝硬化、肝癌,抑制IL-1信号转导途径可能是目前治疗脂肪肝疾病的有效策略。IL-1炎症因子家族多环节多途径地整体调节脂肪肝疾病的发生发展,有望成为有效治疗脂肪肝的药物靶点,指导脂肪肝治疗药物的筛选。该文对近年来关于IL-1炎症因子家族在酒精性和非酒精性脂肪肝疾病中的作用及机制研究进行全面综合、整理和归纳。

Interleukin-1 （ IL-1 ） inflammatory cytokines play a key role in the progression of fatty liver disease, including hepa-titis, hepatic fibrosis, cirrhosis, hepatocellular carcinoma. The IL-1 family cytokines are closely linked with different stages of fatty liver diseases. It was considered as an effective strategy for the treatment of fatty liver diseases via regulating the IL-1 path-way. IL-1 regulates the occurrence and development of fatty liver diseases through many ways and many links. It is expected to bean effective molecular target for the prevention of these d ise a se s , which could be used for fatty liver disease drug screening. This review summarizes the roles and mechanisms of IL-1 family cyto-kines in alcoholic and non-alcoholic fatty liver diseases in recent years.