lncRNA在免疫细胞及自身免疫性疾病中的研究进展

Advances of lncRNA in immune cells and autoimmune diseases

长链非编码RNA(long noncoding RNA,lncRNA)是继miRNA后又一类具有调控功能的非编码RNA,其可在基因水平、转录水平和蛋白质水平等多方面影响疾病的发生发展。目前已在基因印迹、肿瘤疾病、神经退行性疾病等领域取得较好的研究进展,而其在自身免疫方面的研究才刚刚起步,但诸多lncRNA已被证实参与免疫细胞的发育分化,并在免疫系统稳态维持及自身免疫性疾病的发生发展中发挥重要作用。本文将从免疫细胞和自身免疫性疾病方面阐述lncRNA的研究进展。

Long non-coding RNA（lncRNA）is a newly identified non-coding RNA subfamily with various regulatory functions. Recent evidence has shown the fundamental role of long noncoding RNAs in affecting the development of diseases at different levels, from gene modification, transcriptional regulation to protein translation. The study on lncRNA has made great progress in the studies of genomic imprinting, cancer diseases and neurodegenerative disorders, while the research relevant to autoimmune diseases has just started recently. However, many lncRNAs have been identified to involve in immune cells proliferation, differentiation and maturation, acting as the key regulators in immune homeostasis and autoimmune diseases. This review is focused on the advances of lncRNA in immune cells and autoimmune diseases.