不同剂量艾司洛尔用于无痛胃肠镜镇静麻醉和麻醉复苏的临床研究

Clinical Research of Different Doses of Esmolol During the Sedation and Emergence Anesthesia of Painless Gastroscopy

目的探讨不同剂量艾司洛尔在无痛胃肠镜镇静麻醉与麻醉复苏中的应用效果。方法方便选取2014年5月—2015年12月间于该院进行无痛胃肠镜检查的门诊患者,共164例,ASAⅠ~Ⅱ级。观察组与对照组各82例,为对照组患者应用常规剂量艾司洛尔0.5 mg/kg,为观察组患者则给予1.0 mg/kg艾司洛尔。比较两组静脉麻醉用药的使用剂量,比较两组入睡时间、留观时间以及清醒时间;比较两组用药后不良反应。结果观察组除T0外其他各时段HR、MAP、SO_2等各项指标显著优于对照组,且观察组各时段指标幅度波动较小;观察组用药后无1例出现不良反应发生率,而对照组不良反应发生率为6.1%,观察组用药后不良反应较少;观察组手术检查时间(18.2±2.9)min较对照组(26.4±3.5)min更短。上述所有对比均差异有统计学意义(P<0.05)。结论在剂量选择上给予1.0 mg/kg艾司洛尔可提高临床效果,降低不良反应发生率,减少术中意外情况,从而缩短检查时间。

Objective To observe the clinical application value of different doses of Esmolol during the sedation and emergence anesthesia of painless gastroscopy.Methods 164 patients(ASAⅠ~Ⅱ) of adopting the painless gastroscopy from May2014 to December 2015 in our hospital were convenient selected.82 cases each group,the control group took the conventional doses of Esmolol(0.5mg/kg);the observation group took 1.0mg/kg of Esmolol.The clinical index of drug dosage,time of falling asleep,observation time and recovery time as well as adverse reactions for two groups were compared.Results The observed groups were significantly better than those in the control group except for the other stages,such as HR,MAP,SO_2,And the observed groups were less volatile in each period of time.The incidence of adverse reactions was not 1 in the observed group,while the control group had a 6.1 per cent incidence of adverse reactions,followed by less adverse reactions in the observation group.The observed period(18.2±2.9) min was shorter than the control group(26.4±3.5) min,All of these contrasts are statistically significant(P<0.05).Conclusion Esmolol is much reliable,1.0mg/kg of Esmolol can improve the clinical effect,reduce the adverse event rate,lower the incidence rate of accidents and shorten the examination time.