他汀类药物治疗高血脂合并老年动脉粥样硬化性急性脑梗死对比

Statin Treatment of Hyperlipidemia Combined the Atherosclerotic Process in the Elderly with Acute Cerebral Infarction

目的评价分析3种他汀类药物即阿托伐他汀、瑞舒伐他汀和辛伐他汀对老年高血脂合并动脉粥样硬化性脑梗死患者的临床治疗效果。方法方便选取90例于2014年4月—2016年10月期间到该院就诊高血脂合并老年动脉粥样硬化性急性脑梗死的患者,将其作为研究对象并按照个人意愿进行随机分组,A组30例患者采取阿托伐他汀进行治疗,B组30例患者采取瑞舒伐他汀进行治疗,C组30例患者采取辛伐他汀进行治疗,疗程均要求为2周,对比分析治疗前后各组各项临床指标的差异。结果 A组30例患者治疗后的血脂[TC(4.85±1.31)mmol/L、LDL-C(2.39±0.78)mmol/L、HDL-C(1.63±0.55)mmol/L]、CPR(3.95±2.48)ng/L、NHSS评分(4.84±3.75)分均优于其他两组患者(P<0.05)。结论他汀类药物可以有效缓解和改善老年高血脂合并动脉粥样硬化性急性脑梗死患者的临床症状,阿托伐他汀最为安全有效,瑞舒伐他汀效果次之,辛伐他汀效果一般。

Objective To evaluate the clinical efficacy of three kinds of statins,namely atorvastatin,rosuvastatin and simvastatin,which were used in the elderly patients with hyperlipidemia and atherosclerosis cerebral infarction.Methods Convenient selection 90 patients which with hyperlipidemia and senile atherosclerotic acute cerebral infarction in our hospital from April 2014 to October 2016 were selected,as the research object and randomly grouped according to individual wishes,30 patients in group A take atorvastatin for treatment,30 patients in group B take rosuvastatin for treatment,30 patients in group C take simvastatin for treatment,the course of treatment was 2 weeks,the differences of clinical indexes before and after treatment were compared.Results After treatment,A group of 30 patients with blood lipids[TC(4.85±1.31)mmol/L、LDL-C(2.39±0.78)mmol/L、HDL-C(1.63±0.55)mmol/L],CRP(3.95±2.48)ng/L and NIHSS score(4.84±3.75)points were better than the other two groups of patients(P<0.05).Conclusion Statins can effectively alleviate and improve the clinical symptoms of elderly patients with hyperlipidemia and atherosclerosis cerebral infarction,atorvastatin is the most safe and effective drug,rosuvastatin take the second place,simvastatin has the general effect.