Ki-67表达水平检测在乳腺癌新辅助化疗疗效评估中的价值

The value of Ki-67 expression in neoadjuvant chemotherapy for breast cancer

目的:回顾性分析88例乳腺癌新辅助化疗前、后Ki-67在肿瘤组织的表达情况,探讨Ki-67表达与新辅助化疗疗效的关系,评价其在乳腺癌新辅助化疗中的预测作用。方法:选取2015年9月至2016年9月河北医科大学第四医院乳腺中心收治的88例Ⅱ-Ⅲ期乳腺癌患者,检测新辅助化疗前空芯针穿刺肿瘤组织及术后标本中Ki-67的表达,分析其与新辅助化疗疗效及临床相关病理因素的关系。结果:新辅助化疗的临床总有效率为59.09%(52/88),Ki-67高表达组对化疗敏感,化疗效果明显优于Ki-67低表达组(P<0.05);新辅助化疗可明显降低Ki-67的高表达率(P<0.01);新辅助化疗后Ki-67表达下降组化疗有效率显著高于其他组(P<0.05)。结论:Ki-67在乳腺肿瘤组织中的表达可作为新辅助化疗疗效临床评价指标之一,预测新辅助化疗的疗效,为个体化治疗提供依据。

Objective：To explore the expression of Ki - 67 before and after neoadjuvant chemotherapy in 88 cases of breast cancer and analyze the correlation of Ki - 67 expression with efficacy of neoadjuvant chemotherapy. Assess the prediction value of Ki -67 in neoadjuvant chemotherapy. Methods ： Ki - 6 7 expression in tumor tissues of 88 cases of stage Ⅱ -Ⅲ breast cancer was detected before and after neoadjuvant chemotherapy in the Fourth Hospital of Hebei Medical University in September 2015 to September 2016. Analyze the relationship of Ki - 67 with the efficacy of chemotherapy and neoadjuvant clinical related pathological factors. Results ： Response rate （O R ） of neoadjuvant chemotherapy was 59. 09% （52/88 ）. The over - expression group of Ki - 67 was more sensitive than those with lower -expression （P 〈0. 05）. Positive expression rate of Ki-67 was reduced significantly by neoadjuvant chemotherapy （P 〈0. 01）. The efficacy of neoadjuvant chemotherapy in the decreased expression of Ki -67 group was significantly higher than other group （ P 〈 0. 05 ）. Conclusion ： The expression of Ki - 67 in breast cancer tissue may be used as one of the evaluation index in predicting the curative effect of neoadjuvant chemotherapy and provide a basis for indi-vidualized treatment.