Ⅱ型子宫内膜癌中E-cadherin、β-catenin和HER2的表达及意义

Expression and significance of E-cadherin,β-catenin and HER2 in endometrial carcinoma of Ⅱ type

目的:探讨Ⅱ型子宫内膜癌中上皮钙黏素(E-cadherin,E-cad)、β-连环素(β-catenin,β-cat)和HER2表达的关系及临床病理意义。方法:采用Envision法检测84例Ⅱ型子宫内膜癌中E-cad、β-cat和HER2的表达,分析三者表达与临床病理的关系,并对随访数据资料进行统计学处理。结果:84例Ⅱ型子宫内膜癌中E-cad、β-cat和HER2的阳性表达率分别为52.4%、67.9%和76.2%。Ⅱ型子宫内膜癌中E-cad、β-cat和HER2的表达均与肿瘤TNM分期及淋巴结转移有关(P<0.05),与患者年龄、肿瘤大小及组织学分级无关(P>0.05)。Ⅱ型子宫内膜癌中E-cad表达与β-cat和HER2表达呈负相关(P<0.05),β-cat和HER2表达与临床分期和患者生存率呈负相关(P<0.05)。结论:E-cad可抑制Ⅱ型子宫内膜癌的浸润和转移,与β-cat和HER2表达具有相关性,可能在Ⅱ型子宫内膜癌的发展过程中具有协调作用,联合检测Ecad、β-cat和HER2可能为临床判断子宫内膜癌的预后和个体化治疗提供参考指标。

Objective: To study the expression and significance of E-cadherin( E-cad),β-catenin( β-cat)and HER2 in endometrial carcinoma of Ⅱ type. Methods: Immunohistochemical analyses were performed to detect the expressions of E-cad,β-cat and HER2 in 84 cases of endometrial carcinoma of Ⅱ type,and relationships with clincopathological features were analysed. Results: The positive rate of E-cad,β-cat and HER2 was 52. 4%,67. 9%and 76. 2% respectively. The expressions of E-cad,β-cat and HER2 were correlated with clinical stage and metastasis of lymph nodes( P < 0. 05) and had no correlation with age,size of tumors and classification( P > 0. 05). The expression of E-cad was negative correlated with the expressions of β-cat and HER2( P < 0. 05). The expressions of β-cat and HER2 were significant correlated with the clinical stage and the survival( P < 0. 05). Conclusion: E-cad can inhibit the invasion and metastasis of endometrial cancer of Ⅱtype,associated with β-cat and HER2 expression. The study prompt they have coordination effect in the process of the development of endometrial carcinoma of Ⅱtype. Combining detection of E-cad,β-cat and HER2 may provide the reference for clinical prognosis and individualized treatment.