腹腔热灌注化疗在卵巢癌治疗中的研究进展

卵巢癌是常见的妇科恶性肿瘤之一,其发病隐匿,多数患者发现时已出现盆腹腔内广泛转移的症状。卵巢癌的5年生存率始终停留在30%左右,腹腔种植、术后残存肿瘤细胞是其复发和死亡的重要因素。卵巢癌患者在肿瘤减灭术后行腹腔热灌注化疗可有效清除残存灶,抑制肿瘤细胞再种植,降低复发率及病死率,本文就腹腔热灌注化疗治疗卵巢癌的研究进展做一综述。

Ovarian cancer is one of the common gynecological malignant tumors. It is asymptomatic in its early stages, and the majority of patients are diagnosed only when the disease has metastasized widely in pelvic or abdominal, 5-years survival rates remain about 30%. Peritoneal metastasis, postoperative residual tumor cells are play an important role in its recurrence and death. Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy can efficiently clear the residual tumor, inhibit tumor cells implant again, reduce the morbidity and mortality, which is beneficial for the treatment of ovarian cancer. The main objective of this article was to report results of selected studies of treatment with HIPEC for ovarian cancer patients.