氢溴酸催化的双吲哚甲烷合成

HBr-Catalyzed Synthesis of Bis( indolyl) methanes

采用氢溴酸催化的双吲哚甲烷合成反应.仅使用2 mol%的HBr(40%水溶液)作催化剂,吲哚与羰基化合物便以极高的效率缩合,并生成活性分子双吲哚甲烷.该反应催化剂用量极低却多数在瞬间完成,且条件温和、经济高效、底物适用范围广.

Applying the reaction of HBr-catalyzed synthesis of bis （indolyl）methanes, with the catalysis of only 2 mol% of HBr （40% aqueous） , indoles reacted rapidly with carbonyl compounds to give bis （indolyl） methanes with extremely high efficiency. This reaction features low catalyst loading, quick accomplishing , mild conditions, low cost and wide substrate application scope.