黄连素的临床新用途进展研究

Research on New Clinical Application Progress of Berberine

黄连素是从毛茛科黄连属植物黄连中提取的异喹啉类生物碱,其一直是清热解毒和抗肠道细菌感染的传统良药.近年来发现,黄连素还有治疗Ⅱ型糖尿病、非酒精性脂肪性肝病、血脂异常、高尿酸血症和多囊卵巢综合征等临床新用途,但是目前黄连素的作用机制尚未完全明确,因此,进一步对其作用机制及作用靶点,以及阈剂量、安全性、与其他药物复配的协同机制等进行深入研究,对于黄连素的深度开发和应用具有重大意义.

Berberine, an isoquinoline alkaloid extracted from Rhizoma Coptidis, has been used as a traditional medicine for heat-clearing ,detoxifying and antienterobacterial infection. But recently new clinical applications have been found in the treatment of type Ⅱ diabetes, nonalcoholic fatty liver disease, abnormal blood lipid, hyperuricemia and polycystic ovary syndrome. However, its application mechanism has not been discovered clearly. Therefore, further researches on its mechanism, target, effective threshold dose, safety and the coordination mechanism with other drugs are of great importance for further development and application.