多囊卵巢综合征病因学及诊治进展

Research progress made in the etiology, diagnosis and treatment of polysistic ovary syndrome

多囊卵巢综合征(polysistic ovary syndrome,PCOS)是影响育龄妇女最常见的生殖障碍性疾病,临床主要表现为月经稀发或闭经、无排卵性不孕、肥胖及高雄激素血症,远期并发症主要为高血压、糖尿病和子宫内膜癌。PCOS确切的病因及发病机制尚不明确,目前普遍认为是遗传、环境及社会心理因素等共同作用的结果。由于其临床表现存在高度异质性,关于该病的基础及临床研究一直是研究者关注的焦点,笔者查阅相关文献,对该疾病的病因、诊断及治疗方法的进展进行综述。

Polycystic ovary syndrome （PCOS） is the most common reproductive disorder affecting women of childbearing age. Its main clinical manifestations include oligomenorrhea or amenorrhea, anovulatory infertility, obesity and hyperandrogenemia, and its long-term complications are hypertension, diabetes mellitus and endometrial carcinoma. The exact etiology and pathogenesis of PCOS remains unclear. At present it is widely believed that PCOS is the result of the combination of genetic, environment, social psychological and other factors. Due to its high heterogeneity in clinical manifestations, PCOS has been the focus of many researcher studies. The author referred to the relevent literature, and reviewed the progress made in understanding the etiology, diagnosis and treatment of PCOS.