立体定向微创手术联合术后高压氧及丙戊酸钠治疗脑肿瘤的疗效观察

The observation of curative effects about stereotactic minimally invasive surgery combined with postoperative hyperbaric oxygen and sodium valproate on the treatment of brain tumors

目的:比较观察立体定向微创手术联合术后高压氧及丙戊酸钠治疗脑肿瘤的临床疗效。方法:选取在医院诊治的120例脑肿瘤患者,采用随机数表法将患者分为观察组和对照组,每组60例。观察组采取立体定向微创手术联合术后高压氧及丙戊酸钠治疗;对照组给予单纯立体定向微创手术治疗。比较观察两组患者的临床疗效、不良反应发生情况、术后并发症发生率以及生活质量。结果:经治疗后两组患者治疗有效率、治疗后并发症发生率比较差异有统计学意义(x^2=11.368,x^2=25.145;P<0.05);生存质量中的躯体功能、角色功能、社会功能以及总生活质量等方面,差异均具有统计学意义(t=10.867,t=9.028,t=8.995,t=9.187;P<0.05)。结论:立体定向微创手术联合术后高压氧及丙戊酸钠治疗脑肿瘤具有明显的临床疗效,减少不良反应。

Objective： To observe and compare the clinical efficacy of stereotactic minimally invasive surgery combined with postoperative hyperbaric oxygen and sodium valproate on the treatment of brain tumors. Methods： 120 patients with brain tumors were randomly divided into observation group （60 cases） and control group （60 cases） as the random number table. The patients of observation group were implemented stereotactic minimally invasive surgery combined with postoperative hyperbaric oxygen and sodium valproate, while the patients of control group only were implemented stereotactic minimally invasive surgery. The clinical efficacy, adverse reaction, post-operative complication and living quality of the patients in two groups were observed and compared. Results： After treatment, the difference of curative effects between the two groups was significant （x^2=11.368, P〈0.05）, and the difference of the incidence of complications between the two groups also was significant （x^2=25.145, P〈0.05）. The differences of a series of living quality indicators, such as physical function, role function, social function and total living quality, between the two groups were significant（t=10.867, t=9.028, t=8.995, t=9.187; P〈0.05）. Conclusion： Stereotactic minimally invasive surgery combined with postoperative hyperbaric oxygen and sodium valproate in the treatment of brain tumors can better relieve the state of patients, and it has some clinical efficacy.