心理干预对过敏性紫癜患儿情绪及细胞免疫功能的影响

Influence of psychological intervention on emotion and cellular immune function of children with Henoch-Schonlein purpura

[目的]探讨心理干预对过敏性紫癜患儿的情绪及细胞免疫功能的影响。[方法]选择2013年1月—2014年12月在儿科入住的6岁~14岁无基础疾病的过敏性紫癜患儿,随机分为对照组、观察组,各25例。干预前后采用汉密尔顿焦虑量表(HAMA)和儿童抑郁量表(CDI)对患儿心理状况进行评估,同时采用流式细胞仪定量检测嗜酸性粒细胞及CD_4^+、CD_8^+水平,评价患儿外周血T细胞亚群的分布特点,分析患儿免疫功能状态与情绪变化的相关性。[结果]观察组患儿心理干预后HAMA得分(6.2分±1.2分)低于对照组(7.5分±1.0分),CDI得分(5.8分±1.1分)低于对照组(8.3分±1.0分),外周血嗜酸性粒细胞(EOS)计数(3.153×10~9/L±1.361×109~/L)低于对照组(4.084×10~9/L±2.306×10~9/L),CD_4^+水平(37.10±6.53)%高于对照组(28.20±7.67)%,CD_8^+水平(15.86±3.56)%低于对照组(24.61±5.99)%,CD_4^+/CD_8^+(2.33±0.44)高于对照组(1.15±0.27),两组比较差异均有统计学意义(P<0.05或P<0.01)。[结论]心理干预对改善过敏性紫癜患儿的情绪、提高免疫功能具有重要的实践意义。

Objective To probe into the influence of psychological intervention on emotion and cellular immunefunction in children with Henoch Schonlein purpura. Methods： Children aged 6 to 1 4 yeSchonlein purpura who had no underlying diseases were selected from January 2013 to December 2014. Theywere randomly divided into two groups： control group and observation group^each group with 25 children. The Hamilton Anxiety Scale （HAMA ） and the child depression scale（Children, s ,Depression, Inventory, CDI） were used to assess the psychological status of the children. At the same time, quantitative detection of eosinophils and CD.） and CD8 levels by flow cytometry, the distribution characteristics of T lymphocyte subsets in periph-eral blood of children were evaluated, and the correlation between immune function and emotional changes in children was analyzed. Results： The patients in the observation group after psychological intervention HAMA score（6. 2± 1. 2） was lower than that in control group（7. 5± 1.0） ,CDI score（5. 8± 1. 1 ） wcontrol group（8. 3 ± 1. 0）,peripheral blood eosinophil （EOS ） count （3. 1 53 × 1 09 /L ± 1. 361 × 1 09 /L ） was lower than that in control group（4. 084 × 1 09/L ± 2. 306 × 10 9/ L ）, CD] （37. 10% ± 6. 5 3 % ） was higher than that incontrol group（28. 20%±7. 67%） ,CD （15. 86%±3. 56%） was lower than that in control graup（24. 61%±5. 99%）,the ratio of CD, /CD8 （2. 33 ± 0.44） was higher than that in control group （1. 1 5 ± 0. 27）, the difference be-tween the two groupswas statistically significant（P 〈0. 05 or P 〈0. 01）. Conclusion Psychological intervention had important practical significance for improving the emotion and increasing the immune function of childrenwith Henoch Schonlein purpura.