脂代谢紊乱在非酒精性脂肪肝发病中的作用

Hepatic lipid metabolism and non-alcoholic fatty liver disease

随着肥胖、2型糖尿病、代谢综合征等疾病发病率的增加,非酒精性脂肪性肝病(NAFLD)全球患病率也逐年递增.其发病机制较为复杂,通常伴随着胰岛素抵抗、脂代谢紊乱、脂毒性凋亡、炎症反应失调等现象.本文着重对脂代谢紊乱在NAFLD中的作用及其机制进行了综述,同时对细胞脂毒性、胰岛素抵抗及肠道菌群紊乱在其中的作用也进行简要描述,旨在为NAFLD的预防和治疗提供新思路.

The prevalence of non-alcoholic fatty liver disease （NAFLD） along with the metabolic diseases such as obesity, type 2 diabetes and metabolic syndrome keeps rising worldwide. Unfortunately, our understanding of what causes NAFLD at the molecular level remains mostly speculative. Insulin resistance, lipotoxicity and inflammation may be involved in the pathogenesis of this disease. In the current review, we discuss the role of disturbed lipid metabolism in the development of NAFLD, and overview other altered factors that may participate in this process, including lipotoxicity, insulin resistance as well as intestinal flora disorder. Our aims are to provide new insights into prevention and potential therapeutic strategies for NAFLD.