四川大学华西医院8944例健康体检女性HPV感染情况分析

Analysis of HPV infection among 8944 females of health examination in West China Hospital of Sichuan University

目的研究四川大学华西医院8 944例健康体检女性HPV感染情况及其基因型分布。方法纳入四川大学华西医院体检健康中心2016年1月至9月行HPV检测的8 944例健康体检女性。HPV基因分型检测采用Luminex流式荧光技术进行,使用Excel 2007及SPSS 17.0软件分析HPV感染情况及基因型分布。结果 8 944例体检女性的HPV感染率为14.4%(1 291/8 944)。其中单一感染1 025例,感染率为11.5%(1 025/8 944),多重感染266例,感染率为3.0%(266/8 944);20~25岁和66岁及以上年龄段在单一及多重感染中的感染率均较其他年龄段有明显增高。在单一和多重感染中,4种最普遍的基因型依次均为HPV52、53、16和58,单一感染中HPV52感染率最高,且在31~35岁和61~65岁年龄段均有增高,多重感染中HPV52和16在20~25岁年龄段的感染率均有增高。结论根据本院健康体检女性HPV感染和基因型分布情况,建议将HPV52、53和58纳入到HPV疫苗筛选评估中。

Objective To investigate HPV infection, genotype distribution of HPV infection among 8 944 females of health examination in West China Hospital of Sichuan University. Methods We enrolled 8 944 females of health examination in West China Hospital of Sichuan University from January to September in 2016. HPV genotyping was performed by Luminex fluorescence technique. Excel 2007 and 8PS8 17.0 softwares were used to analyze the infection and genotype distribution of HPV. Results The HPV infection rate of 8 944 health examination women was 14.4% （1 291/8 944）. Among them, there were 1 025 cases of single infection, the infection rate was 11.5% （1 025/8 944）; there were 266 cases of multiple infection, the infection rate was 3.0% （266/8 944）. The infection rates of 20 to 25 years and ≥66 years groups in single and multiple infection were higher than other age groups. In the single and multiple infections, the most common genotypes were HPV52, 53, 16 and 58. Infection rate of HPV52 was the highest in single infection, which had two increased age groups including 31 to 35 years and 61 to 65 years old. Infection rate of HPV52 and HPV16 were increased in 20 to 25 years old group of multiple infections. Conclusion In view of the prevalence of HPV infection among health examination females and the genotype distribution, we recommend incorporating HPV52, 53 and 58 into future vaccine screening.