survivin在涎腺腺样囊性癌组织中表达及意义的Meta分析

The expression and clinical significance of survivin in salivary gland adenoid cystic carcinoma:a Meta analysis

目的:系统评价survivin的表达与涎腺腺样囊性癌(SACC)的临床病理特征之间的相关性。方法:计算机检索PubMed、Embase、Cochrane Library、web of science、OVID、Springerlink、中国学术期刊全文数据库(CNKI)、中国生物医学数据库(CBM)、万方、重庆维普等数据库。根据各研究间的异质性,采用固定或随机效应模型合并比值比(ORs)和相应的95%可信区间(CIs),分析survivin表达与SACC的关联。结果:共纳入10个病例对照研究,包括367例SACC患者及124例正常对照。Meta分析结果显示:survivin在SACC组织中高表达(OR=38.26,95%CI:17.37~84.29,P<0.01),还与病理分型(OR=0.3,95%CI:0.17~0.55,P<0.01)、临床分期(OR=0.23,95%CI:0.13~0.42,P<0.01)以及淋巴结转移(OR=3.7,95%CI:1.82~7.56,P<0.01)有关,差异有统计学意义。结论:survivin的表达可能与SACC临床病理特征相关,但受纳入文献数量及质量的影响,尚需累积大样本高质量的研究来进一步证实。

Objective：This Meta-analysis was performed to explore the association between survivin expression and clinical pathological features of salivary gland adenoid cystic carcinoma （SACC）. Method： Literature was searched in some databases such as PubMed, Embase, Cochrane Library, web of science, OVID, Springerlink, CNKI, CBM, Wanfang and CQVIP. The pooled odds ratios （ORs） and 95 % confidence intervals（95 % CIs） were es- timated to determine the correlation between survivin expression and SACC using a fixed or random effects model according to heterogeneity. Result：A total of ten studies with 367 SACC patients and 124 normal control subjects were included in this Meta-analysis. The results showed that survivin was overexpressed in SACC tissues （OR = 38.26, 95% CI：17.37-84.29, P〈0.01）. It also revealed significant correlations between survivin expression and pathological types （OR =0. 3, 95 % CI ： 0.17 - 0.55, P〈 0.01 ）, advanced tumor clinical stages （OR = 0. 23, 95% CI： 0. 13-0.42, P〈0.01） and lymph node metastasis（OR=3.7, 95% CI：1. 82-7, 56, P〈0.01）. Conclu- sion：The current study demonstrated that survivin expression may be associated with the clinical pathological fea- tures of SACC. However, due to the influence of the quantity and quality of the included literature, additional high quality of studies with larger sample sizes are needed to confirm our findings.