上下气道炎症评估方法的标准化

The standardization of inflammation detecting methods in upper and lower airways

目的:建立标准化的上下气道炎症评估方法。方法:通过对上下气道炎性疾病的相关课题的研究,摸索出上下气道炎症评估(鼻肺部NO、气道高反应性及细胞学)的方法及相应正常值。结果:鼻部NO正常值范围为400~900ppb,肺部为5~25ppb;鼻激发后鼻阻力较基础值增加≥100%,支气管激发FEV1较基础值下降≥20%,判定为阳性;鼻灌洗Eos≥2.00/HP,诱导痰Eos≥2.5%为阳性。结论:上下气道炎症评估方法的标准化为上下气道的后续研究提供了相关的方法学及研究基础。

Objective：To investigate the standardization of inflammation detecting methods in upper and lower airways. Method： After a five year cooperation with Guangzhou Institute of Respiratory Diseases on inflammatory diseases of airways, we have found a series of evaluation methodology and normative values in upper and lower air- ways（NO）, airway hyper reactivity and cytology（Eos）. Result：The normative range of nasal and pulmonary NO is 400-900 ppb and 5-25 pph respectively. The nasal resistance increased ≥100% and FEV1 fell ≥20% when compared with their respective baselines-both illustrating a positive result. The positive value of nasal and pulmo- nary Eos are ≥2.00/HP and ≥2.5% respectively. Conclusion：The standardization of evaluation methods for up- per and lower airway inflammation provides the methodology and research basis for follow-up studies of upper and lower airways.