CT评价主动脉弹性与冠状动脉钙化的相关性

Correlation between aortic elasticity and coronary artery calcification evaluated by CT

目的采用CT探讨主动脉弹性与冠状动脉钙化的相关性。方法搜集我院拟诊为冠心病并接受冠状动脉CTA检查病例,将图像质量能满足主动脉弹性测量的111例患者纳为研究对象,分为钙化阴性组(n=43)和钙化阳性组(n=68),根据钙化积分值将钙化阳性组分为轻度、中度、重度钙化3组。将原始数据每隔5%R-R间期进行全时相自动离线重建,测量各R-R间期主动脉横截面积及直径,计算评价主动脉弹性的4个参考指标:直径变化率(%A0)、动脉可扩张度(A0D)、动脉顺应性(A0C)及动脉僵硬度(A0SI)。分析主动脉弹性与冠状动脉钙化的关系。结果钙化阳性组的%A0、A0D、A0C小于钙化阴性组,而A0SI大于钙化阴性组(P均<0.05)。钙化阳性组中轻度、中度、重度钙化3组间主动脉弹性差异无统计学意义(P均>0.05)。冠状动脉钙化积分与%A0、A0D、A0C呈负相关,与A0SI呈正相关。结论主动脉弹性与冠状动脉钙化积分有相关性,两者联合应用可以为早期诊断冠心病提供依据。

Objective To discuss the correlation between aortic elasticity and coronary artery calcification by CT. Methods To- tally 111 patients who were diagnosed of coronary artery disease underwent coronary artery CTA. The images were qualified for aortic elasticity measurement. All patients were divided into calcification negative group （n= 43） and calcification positive group （n = 68）. The calcification positive group was further divided into light, medium, and serious groups according to their calcification scores. The ascending aortic images were reconstructed every 5% R-R intervals. The cross-sectional areas and diameters of aortic in each R-R interval were measured automatically, then diameter variation rate （ %A0 ）, aortic distensibility （A0D）, aortic compli- ance （A1, C） and aortic stiffness （A0 SI） were calculated to evaluate aortic elasticity. Correlation between aortic elasticity and coro- nary artery calcification were analyzed. Results % A0, A0 D, A0 C were lower and A0 SI was higher in calcification positive group than those in calcification negative group （all P〈0.05）. There was no significant differences in the four reference indexes of aortic elasticity among light, medium, and serious groups in calcification positive group （all P〈0.05）. Correlation analysis demonstrated negative correlations between ~A0, AoD, A0 C and calcification scores, and a positive correlation between A1SI and calcification scores. Conclusion Aortic elasticity is correlated with coronary artery calcification, and the combination of them will be beneficial for the early diagnosis of coronary heart disease.