卵巢巧克力囊肿介入治疗前后血清CA125分析

Analysis of serum CA125 level of patients with ovarian chocolate cysts before and after interventional therapy

目的探讨卵巢巧克力囊肿患者血清CA125水平的影响因素及介入治疗对血清CA125水平的干预作用。方法对103例单侧卵巢单发巧克力囊肿患者行超声引导下介入治疗,并依据治疗前患者血清CA125水平分为正常组(CA125≤35U/ml)和异常组(35U/ml<CA125≤200U/ml)。比较两组患者临床指标及囊肿超声特征的差异,并分析介入治疗前后血清CA125水平的变化。结果两组间病程、痛经史、囊肿最长径差异均有统计学意义(P均<0.05),年龄、生育史、流产史、盆腔手术史、囊肿位置差异均无统计学意义(P均>0.05)。与治疗前相比,异常组治疗后3个月(P<0.000 1)及治疗后6个月(P<0.000 1)患者血清CA125减低。正常组治疗后3个月及治疗后6个月患者血清CA125均与治疗前差异无统计学意义(P均>0.05)。结论痛经史、病程、囊肿直径均可影响巧克力囊肿患者血清CA125水平。超声引导下介入治疗对治疗前血清CA125水平已存在异常的巧克力囊肿患者的血清CA125水平具有干预作用。

Objective To investigate the influence factors of serum CA125 level in patients with ovarian chocolate cysts, and to study the effect on serum CA125 level of interventional therapy. Methods A total of 103 patients with single unilat- eral chocolate cyst of ovary underwent interventional treatment. According the serum CA125 level before interventional therapy, the patients were divided into normal group （CA125≤35 U/ml） and abnormal group （35 U/ml〈CA125≤200 U/ml）. The clinical indexes of patients and ultrasound characteristics of cyst were compared between the two groups. The changes of serum CA125 levels before and after interventional therapy were analyzed. Results The difference of the course of diseases, dysmenorrhea history, diameter of cysts had statistical difference between the two groups （all P~ 0.05）. There were no statistical differences of age, history of dilivery, abortion history, history of pelvic surgery, cyst lo- cation between the two groups （all P〉0. 05）. In abnormal group, the mean serum level of CA125 reduced at 3 months （P〈0. 000 1） and 6 months （P〈0. 000 1） after interventional therapy. In the normal group, there was no significant difference of the mean serum level of CA125 before and after interventional therapy （all P〉0. 05）. Conclusion Serum CAl25 level is influenced by dysmenorrhea history, course of disease, diameter of cysts. Ultrasound-guided interventional therapy has intervention effect on patients with abnormal serum CA125 level before interventional therapy.