脂肪源性干细胞治疗阴茎勃起功能障碍的研究进展

Adipose-derived stem cells for the treatment of penile erectile dysfunction:An update

脂肪源性干细胞(ADSCs)是从脂肪组织中分离得到的一种多能干细胞,具有自我更新和多向分化潜能,可向神经细胞、平滑肌细胞及内皮细胞等多种细胞类型分化。而勃起功能障碍(ED)是一种常见的男性性功能障碍疾病,对患者及其伴侣的生活造成了很大的负面影响。目前治疗ED的方法有手术及药物等,其中5-磷酸二酯酶抑制剂作为临床治疗ED的一线用药,仍对少部分患者不敏感,而且存在无法改善或者治愈ED的病理基础。迄今为止的动物试验及临床前期研究已经证实了ADSCs治疗ED的安全性及有效性,其可通过旁分泌作用达到治疗ED的作用。本文就近5年来ADSCs治疗ED的研究进展进行综述。

Adipose-derived stem cells （ADSCs） are pluripotent stem cells isolated from the adipose tissue and have the potential for self-renewal and multi-directional differentiation into neurogenic cells, smooth muscle cells, endothelial cells, and so on. Erectile dysfunction （ED） is a common male sexual dysfunction that has a negative impact on the lives of the patients and their partners. Cur- rent treatments of ED include surgery and medication, with oral 5-phosphodiesterase inhibitors as the first-line drugs. However, a small number of the patients are not sensitive to these therapies and cannot be improved or cured pathologically. So far, animal experiments and preclinical trials have confirmed the safety and efficacy of ADSCs, which act on ED though paracrine mechanisms. This review summarizes the advances in the recent 5 years in the studies of ADSCs for the treatment of ED.