川木香中倍半萜类化学成分的研究

Studies on sesquiterpenes from Vladimiria souliei

目的对川木香Vladimiria soulie根中倍半萜类成分进行研究。方法采用正相硅胶柱色谱、Sephadex LH-20柱色谱、中压色谱、薄层制备、反相高效液相色谱等方法进行分离纯化,并根据其理化性质和波谱数据等鉴定化合物的结构。结果从川木香根中共分离得到了9个化合物,分别鉴定为15-乙酰氧基-11αH-吉玛烷-1(10)E,4E-二烯-12,6α-内酯(1)、15-乙酰氧基-11βH-吉玛烷-1(10)E,4E-二烯-12,6α-内酯(2)、12-羟基-5α(H),7α(H)-桉叶烷-4(14),11(13)-二烯-9-酮(3)、oplodiol(4)、dihydroestafiatone(5)、10-oxo-dihydroxy-11β,13-dihydrodehydrocostuslactone(6)、(11S)-13-羟基-愈创木烷-4(15),10(14)-二烯-12,6α-内酯(7)、9-氧橙花叔酮(8)、vernopolyanthone(9)。结论化合物1和3为新化合物,分别命名为川木香烃二酯和川木香二烯酮;化合物4~9首次从川木香根中分离得到。

Objective To study the sesquiterpenes from the roots of Vladimiria souliei. Methods The compounds were isolated by silica gel, Sephadex LH-20, medium pressure chromatographic column, preparative-TLC, and preparative-HPLC. And their structures were identified by means of chemical methods and spectroscopic analyses. Results Nine compounds were isolated from V. souliei, and named as 15-acetoxy-11αH-germacra-1（10）E,4E-diene-12,6α-olide（1）, 15-acetoxy-11βH-germacra-1（10）E,4E-diene-12,6α-olide（2）, 12-hydroxy-5α（H）,7α（H）-eudesm-4（14）,11（13）-diene-9-one（3）, oplodiol（4）, dihydroestafiatone（5）, 10-oxodihydroxy-11β,13-dihydrode hydrocostuslactone（6）,（11S）-13-hydroxyl-guaia-4（15）,10（14）-diene-12,6α-olide（7）, 9-oxonerolidol（8）, and vernopolyanthone（9）. Conclusion Compounds 1 and 3 are new compounds, named as vlasoudide and vlasoudione; and compounds 4—9 are isolated from the roots of V. souliei for the first time.