党参化学成分的研究

Study on chemical constituents of Codonopsis pilosula

目的对党参Codonopsis pilosula的水提物进行化学成分研究。方法综合采用硅胶柱色谱、ODS柱色谱、Sephadex LH-20和半制备液相等技术进行分离纯化,采用各种波谱技术确定化合物的结构。结果在党参水提物的50%乙醇洗脱部位得到7个化合物,分别鉴定为(-)-(8R,9R,2E,6E,10E)-tetradeca-2,6,10-triene-4-yne-8,14-diol-9-β-D-glucopyranoside(1)、苯基-β-D-葡萄糖苷(2)、(E)-异松柏苷(3)、松柏苷(4)、丁香苷(5)、芹菜素(6)、腺苷(7)。结论化合物1为新党参炔醇苷类化合物,命名为党参炔苷A;化合物2和3为首次从党参中分离得到。

Objective To study the chemical constituents of Codonopsis pilosula. Methods The chemical constituents were isolated and purified by AB-8 macroporous adsorption resin, silica gel, and Sephadex LH-20 column chromatography. The structures of the isolated compounds were identified on the basis of spectroscopic methods including ^1H-NMR, ^13C-NMR, CD, and MS spectra. ResultsSeven compounds were identified as（-）-（8R,9R,2E,6E,10E）-tetradeca-2,6,10-triene-4-yne-8,14-diol-9-β-D-glucopyranoside（1）, phenyl-β-D-glucoside（2）,（E）-isoconiferin（3）, coniferin（4）, syringin（5）, apigenin（6）, and adenosine（7）. Conclusion Compound 1is a new compound, named lobetyolin A, and compounds 2 and 3 are all isolated from this plant for the first time.