香豆素-3-羧酸丹皮酚酯的合成及表征

Synthesis and characterization of Coumarin-3-carboxylic Acid Paeonol Ester

目的:为寻找抗血小板聚集药物,合成香豆素-3-羧酸丹皮酚酯。方法:以水杨醛、丙二酸二乙酯为原料,合成得到香豆素-3-羧酸,再与丹皮酚缩合成酯,得到目标化合物香豆素-3-羧酸丹皮酚酯。结果:设计合成了香豆素-3-羧酸丹皮酚酯,目标物的化学结构经IR,MS,1H-NMR等确证。结论:该合成方法具有工艺简单,产率较高,操作方便等优点。

Objective： To search for effective anti platelet aggregation drugs to synthesize eoumarin-3-carboxylic acid paeonol ester. Methods： Salicylide reacted with diethyl malonate under piperidine catalysis, then coumarin-3-carboxylic acid was gained through hydrolysis and acidification. The target compound was obtained by coupling coumarin-3-earboxyl- ic acid with paeonol. Results： Coumarin-3-carboxylie acid paeonol ester was synthesized. The chemical structure of the target compound was confirmed by IR, MS, and 1H-NMR spectra. Conclusion： The advantages of the synthesis method are simple process, high yield and convenient operation.