茵栀解毒颗粒保护肝损伤药理作用的研究

The Pharmacological Action Study of Yinzhi Jiedu Granules to Protect Liver Injury

为评价茵栀解毒颗粒对肝损伤保护的药理作用,采用四氯化碳引起小鼠肝损伤模型,考察茵栀解毒颗粒保护肝损伤的作用。结果显示,茵栀解毒颗粒对肝脏指数影响差异不显著,中剂量组ALT显著低于阳性对照组(P<0.05),AST极显著低于阳性对照组(P<0.01),ALP各试验组与阳性对照组均无显著差异(P>0.05);低剂量组CAT活力显著高于阳性对照组(P<0.05),高剂量组SOD极显著高于阳性对照组(P<0.01),CAT显著高于阳性对照组(P<0.05);肝脏组织切片显示,低剂量组大部分动物的肝脏细胞形态均正常,未见变性、死亡等现象,中剂量组和高剂量组的肝组织结构正常。结果表明,茵栀解毒颗粒具有明显的保护肝损伤的作用。

The aim of this study was to investigate the pharmacological effects of Yinzhi Jiedu Granule on liver injury, liver injury mouse model caused by CC14 was selected for the research to evaluated the effects of Yinzhi Jiedu Granule in protection of hepatic injury. The results showed that effect of Yinzhi Jiedu Granule on liver index was not significantly different, ALT in the middle dose group was significantly lower than that in positive control group（P〈0.05） ,AST was extremely significantly lower than that in positive control group（P〈0.01 ）, ALP in all experimental groups was no significantly difference than that in positive control group（P〉0.05） ; CAT activity in the low dose group was significantly higher than that in positive control group（P〈0.05）, SOD activity in the high dose group was extremely significantly higher than that in positive control group（P〈0.01 ）, CAT activity in the high dose group was significantly higher than that in positive control group（P〈0.05） ; Liver tissue sections showed that the liver cells of most samples in the low dose group were normal, and there was no degeneration and death. The liver tissues of the middle and the high dose group were normal. These results showed that Yinzhi Jiedu Granule has obvious effect of protecting liver injury.