血栓抽吸联合山莨菪碱对ST段抬高心肌梗死患者行直接经皮冠脉介入治疗的影响

Effects of Thrombus Aspiration Combined with Anisodamine on Patients with ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention

目的观察分析血栓抽吸联合山莨菪碱对ST段抬高心肌梗死患者行直接经皮冠脉介入治疗的临床效果。方法我院心内科收治的直接经皮冠脉介入的ST段抬高心肌梗死患者160例,随机进行分组,两组患者经过诊断性冠状动脉造影后,观察组给予山莨菪碱快速注射,对照组给予肝素快速注射,观察两组患者临床治疗情况。结果观察组校准TIMI计帧数(cTFC)、CK-MB峰值明显低于对照组(P<0.05);观察组手术后的TMPG2-3级比例、完全ST段回落率术后90分钟内(STR)比例明显高于对照组(P<0.05);两组术后TIMI3级比例差异有统计学意义(P<0.05);入院24 h内两组患者的左心室分数(LVEF)、左室舒张末期内经(LVDd差异无统计学意义(P>0.05),术后6个月的随访结果观察组患者的LVEF、LVDd明显优于对照组。结论 ST段抬高型心肌梗死患者行直接经皮冠状动脉介入治疗中,行血栓抽吸经血栓抽吸导管注射山莨菪碱,不仅可改善心肌灌注而且还可有效改善术后心室收缩的能力。

Objective To observe the clinical effect patients with ST-segment elevation myocardial infarction of thrombectomy combined with anisodamine on undergoing percutaneous coronary intervention. Methods One hundred and sixty patients with ST-segment elevation myocardial infarction undergoing direct percutaneous coronary intervention were randomly divided into two groups. After the diagnosis of coronary angiography, the patients in the observation group were injected with anisodamine, The patients were treated with heparin by rapid injection and the clinical treatment was observed. Results The peak values of CTFC and CK-MB in the observation group were significantly lower than those in the control group（ P 〈0.05 ）. The TMPG2-3 ratio and complete STR ratio in the observation group were significantly higher than those in the control group （P 〈 0.05 ） （P 〉 0. 05 ）. There was no significant difference in LVEF and LVDd between the two groups（ P 〉 O. 05 ）. The follow-up results of the 6-month follow-up were not significantly different between the two groups Ventricular fraction （ LVEF）, left ventricular end- diastolic （ LVDd ） were significantly controlled group data. Conclusion ST-segment elevation myocardial infarction patients undergoing direct percutaneous coronary intervention, thrombectomy aspiration by thrombus aspiration catheter anisodamine can not only improve myocardial perfusion, but also can effectively improve the postoperative ventricular contraction capacity.