短暂性癫痫性遗忘的临床和电生理研究(附6例报告)

Electroclinical aspects of the transient epileptic amnesia

目的探讨短暂性癫痫性遗忘(TEA)的临床和电生理特点。方法对本院脑电监测中心收治的6例TEA患者的临床和电生理特点进行研究。结果 6例患者,女性4例,男性2例,年龄34~74岁。除有癫痫性遗忘发作外,还伴有自动症、部分继发全面强直阵挛发作(s GTCS)、"愣神"等其他癫痫发作形式,5例患者的脑电图均为颞导(单侧或双侧)痫样放电,1例正常。其中5例均给予抗癫痫药物治疗,随访1 y,3例无临床发作,2例偶有发作。结论 TEA常常被误诊或漏诊,尽管大多数颞叶癫痫为难治性癫痫,我们的研究提示伴有TEA的颞叶癫痫对抗癫痫药物反应良好。

Objective To investigate the clinical and electrophysiological aspects of the transient epileptic amnesia. Methods We studied the clinical and electrophysiological characteristics of 6 patients diagnosed as TEA（ transient epilep- tic amnesia）. Results The age of 6 patients was ranging from 34 to 74 years old. The seizure types of them had amnesia, automatism,sGTCS,or a brief period of unconsciousness. The epileptiform discharge in the temporal region（unilateral or bi- lateral）was recorded in 5 patients. The other one patient＇ EEG was normal. 5 patients were treated with antiepileptie drugs. 3 patients were seizure free for a year, and 2 patients had epileptic seizures. Conclusion TEA is often misdiagnosis or missed diagnoses. Although the majority of temporal lobe epilepsy is reported as resistant to AEDs, our study suggested that temporal lobe epilepsy with TEA responded well to AEDs.