CuBr_2/Ag_2CO_3催化苄胺氧化酰胺化合成N-苄基苯甲酰胺

Synthesis of N-benzylbenzamides using CuBr_2/Ag_2CO_3 catalyzed oxidative amidation of benzylamines

目的建立一种简单、有效地制备N-苄基苯甲酰胺类化合物的方法。方法以苄胺及衍生物为底物、TBHP为氧化剂、HPO(OEt)_2为添加剂,在CuBr_2/Ag_2CO_3的催化下,制备N-苄基苯甲酰胺类化合物。结果和讨论制备了一系列N-苄基苯甲酰胺类化合物,其结构经~1HNMR、^(13)CNMR和HR-MS表征。该反应具有操作简便、原料易得、条件温和等特点。

OBJECTIVE To develop a simple and efficient method to construct N - benzylbenzamides. METHODS N - Benzyl- benzamides could be conveniently obtained from various benzylamine derivatives via CuBr2/Ag2CO3 - catalyzed oxidative amidation reaction,using TBHP as the oxidant and diethyl phosphate as the additive. RESULTS and CONCLUSION The oxidative amidation reaction of benzylamines led to a series of N - henzylbenzamides, which were characterized by 1 HNMR, 13 CNMR and HR - MS. The present protocol has the advantages of simple operation, readily - available starting materials and mild reaction conditions.