摘要
目的观察半枝莲对Lewis肺癌自发转移小鼠肝细胞生长因子(HGF)表达的影响。方法在小鼠右侧腋下皮下接种Lewis肺癌瘤细胞,复制自发转移模型,酶联免疫吸附测定法(ELISA)检测HGF的表达。结果半枝莲作用组的小鼠与空白组比较,HGF表达显著降低。结论半枝莲可能是通过抑制HGF的表达来抑制Lewis肺癌小鼠自发转移的。
Objective To observe theinfluence of Scutellariae barbatae herba on the expression of hepatocyte growth factor （HGF） in mice with spontaneous metastasis of Lewis lung cancer. Methods Lewis lung cancer tumor cells were subcutaneously injected into the right axillary of the mice to establish a spontaneous metastasis model. The expression of HGFwas detectedby ELISA. Results Compared with the control group, the expression of HGF in Scutellariae barbatae herba treated group significantly decreased. Conclusion Scutellariae barbatae herba may suppress the spontaneous metastasis of Lewis lung cancer in mice by inhibition of the expression of HGF.
出处
《食品与药品》
CAS
2017年第3期208-210,共3页
Food and Drug
基金
山东省自然基金课题(项目编号:ZR2009CM078)
山东省中医药科技发展计划项目(项目编号:2009-001)
关键词
半枝莲
LEWIS肺癌
自发转移
肝细胞生长因子
Scutellariae barbatae herba
Lewislung cancer
spontaneous metastasis
hepatocyte growth factor
