原发性眼内淋巴瘤的诊断及治疗

Diagnosis and treatment of primary intraocular lymphoma

原发性眼内淋巴瘤(primary intraocular lymphoma,PIOL)多为弥漫大B细胞淋巴瘤,易被误诊为葡萄膜炎。其恶性程度高,预后差,因此早期诊断并治疗至关重要。PIOL主要检测方法包括细胞学分析、细胞因子检测、免疫细胞化学分析、基因检测等,多种检测方式联合可以提高PIOL确诊率,但眼内组织活检是诊断PIOL的金标准。PIOL治疗尚无统一方案,目前主要以眼内局部化学治疗及眼眶放射治疗为主,多种治疗方法联合可以提高难治性PIOL的疗效。基于此,本文旨在通过综述目前PIOL的诊断及治疗,为临床诊疗提供一定的参考。

Primary intraocular lymphoma （PIOL） is mostly composed by diffuse large B-cell lymphoma with a high degree of malignancy and often masquerades as uvei- tis. Moreover,it has a poor prognosis, therefore the early diagnosis and treatment are very important. Cytology, cytokine analysis, immunohistocheraistry and genetic testing are often used in combination to improve the diagnosis rate of PIOL, however, eye tissue biopsy is the gold standard for diagnosis of PIOL. Currently, since there is no unified treatment program, the main treatment is given priority to local chemotherapy and orbit- al radiotherapy, and the use of multiple therapies can improve the efficacy of refractory PIOL. Base on these, this article reviews the current diagnosis and treatment for provi- ding certain reference.