垂宁方治疗泌乳素型垂体瘤的临床疗效观察

Clinical efficacy of Chuining Decoction on PRL type pituitary tumor

目的探讨垂宁方治疗泌乳素(PRL)型垂体腺瘤的临床疗效,为临床应用提供借鉴依据。方法将2014年1月至2015年1月收治的60例PRL型垂体瘤随机分为A组、B组和C组。A组患者采用垂宁方进行治疗,B组患者采用溴隐亭进行治疗,C组患者采用溴隐亭联合垂宁方进行治疗;治疗6个月及1年时对患者的瘤体积、血清PRL水平及中医症候积分量表得分进行对比评价。结果治疗6个月及1年时C组患者肿瘤大小改善情况明显优于A组和B组,差异有统计学意义(P<0.05);治疗后3组患者血清PRL水平均显著降低(P<0.05),C组血清中PRL水平改善程度显著高于其余两组(P<0.05),且开始治疗后C组患者PRL水平均明显低于A组和B组,差异具有统计学意义(P<0.05);经治疗后C组患者中医证候评价结果明显优于其余两组,差异具有统计学意义(P<0.05)。结论垂宁方治疗PRL型垂体瘤具有理想的治疗效果,可有效抑制瘤体生长,降低患者血清中泌乳素水平,改善患者预后。

Objective To explore the clinical effect of Chuining Decoction on PRL type pituitary tumor. Methods 60 patients of PRL pituitary tumor were randomly divided into group A, group B and group C. The group A was treated with Chuining Decoction. The group B was treated with bromoeriptine. The group C was treated with bromocriptine combined with Chuining Decoction. The patient＇s tumor volume, serum PRL level and TCM syndrome integral quantities scores were evaluated. Results The tumor size improvement of group C 6 months and 1 year after treatment more obviously improved than that of group A and group B （P〈0.05）. The serum PRL after treatment of the three groups decreased （P〈0.05）. The serum PRL level improvement of group C was was significantly higher than that in the other two groups （P〈0.05）. The PRL level of group C was significantly lower than that of group A and group B （P〈 0.05）. The TCM syndrome evaluation of group C was significantly better than that of group A and group B （P〈0.05）. Conclusion The effect of Chuining Decoction on PRL pituitary tumor is very ideal. Chuining Decoction can effectively inhibit the growth of tumor, reduce the serum prolactin level and improve the prognosis of patients.