COX基因多态性与阿司匹林抵抗相关性的Meta分析

The association between the cyclooxygenase polymorphism and aspirin resistance:a meta-analysis

目的利用Meta分析方法评价心脑血管疾病患者COX基因多态性与阿司匹林抵抗(AR)之间的相关性。方法检索中国生物医学数据库(CBM)、中国学术期刊全文数据库(CNKI)、EMBase、PubMed数据库,收集COX基因多态性与阿司匹林抵抗相关的病例对照研究,提取有效数据,使用stata软件进行Meta分析。结果共纳入13篇文献,共计3995名患者。Meta分析结果表明,COX-1A1676G等位基因在阿司匹林抵抗组和敏感组的差异有统计学意义,COX-1C50T、COX-2G765C基因多态性及等位基因、COX-1A1676G基因多态性在阿司匹林抵抗组和敏感组的差异无统计学意义,亚组分析表明中国人群COX-2G765C基因多态性在阿司匹林抵抗组和敏感组的差异有统计学意义。结论 Meta分析结果表明,COX-1 A1676G等位基因与心脑血管疾病患者阿司匹林抵抗的发生有相关性,中国人群COX-2G765C基因多态性与心脑血管疾病患者阿司匹林抵抗的发生有相关性。

Objective Meta-analysis method was used to evaluate the association between the eyelooxygenase polymorphism and aspirin resistance in the patients with cardiovascular and cerebrovascular diseases. Methods We searched China Biological Medicine （CBM）, China National Knowledge Infrastructure （CNKI）,EMBase and PubMed database. The case-control studies contained cyclooxygenase polymorphism and aspirin resistance were selected. The data were extracted in duplicate and analyzed by STATA software. Results 13 articles with 3995 cases were included. Results There were statisticaliy significant with COX-1 A1676G allele frequency in the aspirin resistance group and the aspirin sensitive group. COX-1 C50T, COX-2 G765C polymorphism and allele frequency, COX-1 A1676G polymorphism were no statistically significant in the aspirin resistance group and the aspirin sensitive group. Subgroup analysis showed that COX-2 G765C polymorphism in the aspirin resistance group and the aspirin sensitive group were statistically significant with Chinese people. Conclusion The meta-analysis showed significant association between the COX-1 A1676G allele and aspirin resistance in patients with cardiovascular and cerebrovascular diseases. The COX-2 G765C polymorphism significant association with aspirin resistance in Chinese people with cardiovascular and cerebrovascular diseases.