铜离子比率荧光探针的研究进展

Research Progress in Copper Ion Ratiometric Fluorescent Probe

比率荧光探针作为一种可视化的新型检测方法,近年来受到广泛关注。比率荧光探针通过峰强度比值的变化扩大动态响应的范围,通过建立内标极大地削弱探针浓度、温度、极性、环境pH值、稳定性等可变因素的干扰,实现对目标物质的定量分析,被广泛应用于重金属离子的检测。综述了近年来铜离子(Cu^(2+))比率荧光探针的合成方法和设计思路,并展望了Cu^(2+)比率荧光探针在分析检测中的应用前景和发展方向。Cu^(2+)比率荧光探针在选择性、灵敏度和可视化程度方面都有了较大的提升,有望成为一种性能优良、应用广泛的功能型荧光传感器。

In recent years, ratiometric fluorescent probe as a new visual detection method, has received ex- tensive attentions. Ratiometric fluorescent probe improves the dynamic response range through the change of peak intensity ratio. In addition,through the establishment of internal standard, the interference of variable factors have been greatly weakened, such as probe concentration, temperature, polarity, pH value of environment, stability of the probe, and the quantitative detection of target analytes has realized. Ratiometric fluorescent probe has been widely applied to detect heavy metal ions. The synthetic methods and the design ideas of copper ion（Cu2＋ ） ratiometric fluorescent probes in recent years are reviewed in this paper. And the application prospect and development direction of Cu2＋ ratiometric fluorescent probe in the analysis and detection are prospected. The results reveal that selectivity, sensitivity and visual degree of Cu2＋ ratiometric fluorescent probe have remarkably improved, and the probe will be expected to be one kind of widely used functional fluorescent sen- sors with excellent performances.