2,2-二(3-硝基-4-羟基苯基)六氟丙烷的合成

Study on Synthesis of 2,2-bis( 3-nitro-4-hydroxyphenyl) Hexafluoropropane

2,2-二(3-硝基-4-羟基苯基)六氟丙烷作为合成2,2-二(3-氨基-4-羟基苯基)六氟丙烷的中间体,其合成对于2,2-二(3-氨基-4-羟基苯基)六氟丙烷的合成至关重要。目前,关于2,2-二(3-硝基-4-羟基苯基)六氟丙烷的合成,共有两种专利方法:美国专利和日本专利。本文将对这两个专利的反应条件进行讨论、比较和分析,分别优化出两个专利的最适宜的反应条件,从而优选出最佳的合成路线。结果表明:日本专利的2,2-二(3-硝基-4-羟基苯基)六氟丙烷的合成方法步骤简单,产率高,适合于工业化生产。

2,2-bis （3-nitro-4-hydroxyphenyl）hexafluoropropane is the intermediate of the synthesis of 2,2-bis （3- amino-4-hydroxyphenyl） hexafluoropropane, which is crucial to synthesize 2,2-bis （3-amino-4-hydroxyphenyl） bexafluoropropane. At present, there are two patented methods for the synthesis of 2,2-bis （3-amino-4-hydroxyphe- nyl） hexafluoropropane ： United states Patent and Japanese Patent. In this paper, the reaction conditions of these two patents are discussed, compared and analyzed. United states Patent and Japanese Patent are investigated separately to determine the appropriate reaction conditions and then the best synthesis way was optimized. The results show that the synthesis method of Japanese Patent is simple and is of high yield,which is fit for industrialization.