丁苯酞联合神经节苷酯治疗一氧化碳中毒迟发性脑病疗效观察

Observation on Curative Effect of Butylphthalide Combined with Gang Hoside in Treating Delayed Encephalopathy with Carbon Monoxide Poisoning

目的探讨丁苯酞联合神经节苷酯治疗一氧化碳中毒迟发性脑病临床疗效。方法回顾分析2010年~2015年我科收治的一氧化碳中毒迟发性脑病患者60例,随机分成对照组和治疗组,每组各30例,对照组应用高压氧及常规治疗,治疗组在高压氧及常规治疗的基础上联合丁苯酞联合神经节苷酯。治疗前及治疗1个月后测定日常生活活动能力量表(BI),痴呆简易筛查量表(BSSD),比较2个量表数值变化,评价临床效果。结果入院时2组患者BI、BSSD评分无显著差异(P>0.05)。治疗1个月后治疗组有效率86 66%,对照组有效率56.66%,治疗组疗效明显优于对照组(P<0.05)。结论丁苯酞联合神经节苷酯治疗一氧化碳中毒迟发性脑病临床疗效显著,值得推广。

Objective Butylphthalide joint Ganglioside clinical curative effect of treatment of DEACME Methods Our department from 2010 to 2015 were retrospectively analyzed in 60 patients with DEACMP, randomly divided into control group and treatment group, each group of 30 cases, the control group used hyperbaric oxygen and routine therapy, in the hyperbaric oxygen treatment group and routine treatment on the basis of joint Butylphthalide and Ganglioside. Before and after 1 month of treatment determination of daily life activities ability scale （BI）, simple screening scale for dementia （BSSD）, compare two scale numerical changes, and evaluate clinical effect. Results BI on 2 groups of patients, BSSD score had no significant difference （P〉0.05）. After 1 month of therapy treatment group effectiveness 86.66%, efficiently control group 56.66%. The treatment group curative effect is superior to the control group（P〈0.05）. Conclusion Butylphthalide joint Ganglioside treatment of DEACMP clinical curative effect, is worth promoting.