老年抑郁症应用度洛西汀与帕罗西汀治疗的效果对照评析

Application of Duloxetine Depression Treated with Paroxetine Effect Evaluation

目的对比老年抑郁症应用度洛西汀与帕罗西汀治疗的临床疗效。方法将我院118例老年抑郁症患者依据治疗方式分成甲、乙两组,每组各有59例患者,甲组应用度洛西汀治疗,乙组应用帕罗西汀治疗,对比两组患者的治疗效果。结果两组患者治疗后HAMD评分均有显著降低(P<0.05),但组间对比无明显差异(P>0.05);甲组痊愈率是61.0%,临床总有效率是84.7%;乙组痊愈率是40.7%,临床总有效率是83.1%,组间临床总有效率对比无显著性差异(P>0.05),而甲组痊愈率要显著高于乙组。结论度洛西汀与帕罗西汀治疗老年抑郁症均能获得较好治疗效果,但度洛西汀具有临床症状改善显著等优势,值得在临床上大力推广应用。

Objective To compare the geriatric depression Duloxetine and Paroxetine clinical curative effect of treatment. Methods Our hospital 118 cases of senile depression patients on the basis of treatment is divided into A, B two groups, each group has 59 patients, A groups was treated with Duloxetine, B groups was treated with Paroxetine, compared the therapeutic effect of two groups of patiems. Results Two groups of patients with HAMD scores were significantly lower after treatment （P〈0.05）, but no difference between the comparison between groups （P〉0.05）; a groups cure rate is 61.0%, the clinical total effective rate is 84.7%; B groups cure rate is 40.7%, the clinical total effective rate is 83.1%, contrast between clinical total effective rate was not significant difference （P〉0.05）, and the cure rate of group A was significantly higher than that of group B. Conclusion Duloxetine and Paroxetine treatment of senile depression can get better treatment effect, but duloxetine has the advantages of the clinical symptoms improved significantly, is worth the clinical promoted application.