妊娠中期甲状腺功能及TPO-Ab检测对预测孕妇并发症的意义

THE SIGNIFICANCE OF THYROID FUNCTION AND TPO-AB DETECTION IN MID-TERM PREGNANCY ON PREDICTING PREGNANT COMPLICATIONS

目的探讨妊娠中期甲状腺功能及TPO-Ab检测对预测孕妇并发症的意义。方法对该院2014年1月—2016年6月住院分娩的220名孕产妇(包括38例临床甲减孕妇、62例亚临床甲减孕妇及120例正常对照组孕妇)检测其早期甲状腺功能及TPO-Ab水平,统计孕妇并发症的发生率。结果孕妇的各种并发症发生率正常对照组、亚临床甲减组、甲减组依次增高,其中妊娠型高血压、早产率、流产率、胎儿宫内窘迫发生率、妊娠出血与正常对照组相比较,P<0.05。正常对照组及亚临床甲减组中孕妇的各种并发症TPO-Ab阳性者发生率明显高于依次增高TPO-Ab阴性者,与TPO-Ab阴性相比较,P<0.05。结论妊娠中期TPO-Ab阳性组较TPO-Ab阴性组发生孕妇并发症的几率显著增高,考虑甲功检测结合TPO-Ab检测的联合应用,对提高亚临床甲减的检出率,减少孕妇并发症具有重要意义。

Objective To explore the significance of thyroid function and TPO- Ab detection during middle of pregnancy to prediction pregnant complications. Methods Totally 220 pregnant women of institutional delivery （38 pregnant women in clinical hypothyroidism group,50 pregnant women in sub - clinical hypothyroidism group and 120 pregnant women in normal control group） were selected as research subjects in author＇s hospital from January 2014 to June 2016. The thyroid function and TPO- Ab were detedeted, and incidence of pregnant complications was recorded. Results The incidences of pregnant complications were increased among three groups. The Hypertensive disorder complicating pregnancy,the rate of premature delivery,abortion,fetal distress and pregnancy were competed with the normal control group, P〈0.05. The incidences of pregnant complications with TPO- Ab positive were higher than the TPO - Ab negative in the normal control group and subclinical hypothyroidism group,P〈0.05. Conclusion The chance of pregnant complica- tions with TPO- Ab postie is significantly higher,it is necessary to apply the TPO- Ab in thyroid function detection,improve the rate of the sub-clinical hypothyroidism and reduce the pregnant complications.