自拟止咳汤联合热毒宁治疗慢性支气管炎急性发作期临床观察

Clinical Observation of Using Self-made Antitussive Decoction Combined with Reduning in the Treatment of Acute Exacerbation of Chronic Bronchitis

目的:观察自拟止咳汤联合热毒宁治疗慢性支气管炎急性发作期的临床疗效。方法:选取2013年5月~2015年6月我院儿科收治130例慢性支气管炎急性发作患儿为研究对象,按随机数字表法分为对照组和观察组,每组65例,对照组患儿给予热毒宁注射液,剂量按3~8岁0.5~0.8ml(kg·d),1次/天,观察组患儿在对照组基础上给予自拟止咳汤,水煎2次共取汁100ml左右,3~8岁患儿1或2剂/天,9~14岁1剂/天,分3次服用,疗程均为10天。比较两组患儿治疗总有效率、治疗前后血气分析变化情况及两组患儿临床症状、体征评分和炎性指标变化情况。结果:观察组患儿治疗有效率明显高于对照组,差异具有统计学意义(χ2=4.993,P<0.05)。治疗后观察组患儿临床症状、体征评分和炎性指标改善程度均明显优于对照组,差异具有统计学意义(P<0.05)。结论:自拟止咳汤联合热毒宁治疗慢性支气管炎急性发作期疗效确切,在缓解患儿临床症状和体征疗效上明显优于单独热毒宁治疗,且安全性高,值得临床推广使用。

Objective： To observe the clinical effect of Serf-made Antitussive Decoction combined with Reduning in the treatment of acute exacerbation of chronic bronchitis. Methods ： From May 2013 to June 2015, 130 acute tracheitis-bronchitis infants with fever were divided into controlled group and observation group according by random number table with 65 cases in each group. The controlled group was treated with Reduning Injection, the dosage was 0. 5 ~0. 8ml/ （kg. d） for the chidren at 3 to 8 years old, 1 time/d, the observation group was additionally treated with Self-made Antitussive Ddecoction on the base of the controlled group, decoction 2 times a total of about 100 ml juice, 1 or 2 time for the 3 - 8 years old children, 3 times for one day, the course of treatment was 10 days. The total effective rate, blood gas analysis, scores of clinical symptoms and signs and inflammatory parameters were compared between the two groups. Results： The effective rate in the observation group was signifi- cantly higher than that in the controlled group （ Xz = 4. 993, P 〈 0. 05 ）. After treatment, the improvement of scores of clinical symptoms and signs and inflammatory parameters in the observation group was significantly better than that in the controlled group （P 〈 0. 05）. Conclusion ： Self-made Antitussive Decoction combined with Reduning is effective in the treatment of acute exac- erbation of chronic bronchitis. It can relieve the clinical symptoms and signs in patients, with high safety.