生脉散合丹参饮加减对2型糖尿病伴冠心病患者血小板粘度、血管内皮功能及冠脉血流量的影响

Effect of Shengmai Powder Combined with Modified Danshen Decoction on Platelet Viscosity,Vascular Endothelial Function and Coronary Blood Flow for Patients with Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease

目的:观察生脉散合丹参饮加减对2型糖尿病(DM)伴冠心病(CHD)患者血小板粘度、血管内皮功能及冠脉血流量的影响。方法:选取2014年10月~2016年4月我院98例DM伴CHD患者,随机按1:1比例分为对照组和治疗组,对照组给予常规治疗,治疗组给予生脉散合丹参饮加减+常规治疗,治疗8周,观察两组疗效、治疗前后血小板粘度、血管内皮功能及冠脉血流量变化。结果:治疗组治疗总有效率91.84%,对照组75.51%,两组差异具有统计学意义(P<0.05)。两组治疗后血浆FⅦ:C、GMP-140、SFMC和F1+2水平均显著下降,血清NO水平显著上升,ET水平显著下降,LVEF、E/A值及LAD血流量均显著上升,且治疗组下降或上升水平大于对照组,差异具有统计学意义(P<0.05)。结论:生脉散合丹参饮加减可显著提升2型糖尿病伴冠心病患者治疗效果,减少血小板粘度,改善血管内皮功能,提升冠脉血流量,临床治疗意义显著,值得推广。

Objective ： To investigate the effect of Shengmai Powder combined with Modified Danshen Decoction on platelet vis- cosity, vascular endothelial function and coronary blood flow in patients with type 2 diabetes mcllitus （T2DM） complicated with coronary heart disease （CHD）. Methods：From October 2014 to April 2016, 98 patients with T2DM complicated with CHD equally divided into treatment group and controlled group. The controlled group was given routine treatment, while the treatment group was treated with Shengmai Powder combined with Modified Danshen Decoction and routine treatment. All patients were treated for 8 weeks. The curative effect, platelet viscosity, endothelial function and coronary blood flow were observed before and after treat- ment. Results ： The total effective rate of the treatment group was 91.84% while in the controlled group was 75.51% （ P 〈 0.05 ）. After treatment, the levels of plasma FV~ ： C, GMP-140, SFMC, F1 ＋2, ET decreased significantly, serum NO, LVEF, E/A and LAD increased significantly, and the changes in the treatment group were greater than those in the controlled group （ P 〈 0. 05）. Conclusion：Shengmai Powder combined with Modified Danshen Decoction can significantly improve the curative effect in pa- tients with T2DM and CHD, reduce platelet viscosity, improve endothelial function and coronary blood flow.