补骨健膝方配合针灸疗法与单纯针灸疗法对风寒湿痹型膝骨关节炎的疗效比较及对相关指标的影响

Therapeutic Effects Comparison Between Acupuncture Combined with Bugu Jianxi Recipe and Simple Acupuncture for Knee Osteoarthritis and the Impact on Relavent Indexes

目的:观察针灸配合补骨健膝方治疗风寒湿痹型膝骨关节炎的临床疗效,并对其相关的指标进行检测。方法:选取109例膝骨关节炎患者随机分为对照组和观察组,对照组53例,观察组56例,对照组患者采用针灸治疗,每天1次,15天为1个疗程,连续治疗3个疗程;观察组采用针灸配合补骨健膝方治疗,每日1剂,分早晚2次饭后温服,15天为1个疗程,连续治疗3个疗程。检测2组患者治疗前后关节液中白介素lβ(IL-lβ)、肿瘤坏死因子α(TNF-α)及白介素6(IL-6)的含量,并进行统计分析,同时比较治疗后2组患者的血液流变学、膝关节功能以及临床疗效。结果:治疗后2组患者关节液中IL-lβ、TNF-α及IL-6的水平明显低于治疗前(P<0.05),并且治疗后观察组患者的变化程度显著较对照组明显(P<0.05)。治疗后2组患者的膝关节功能评分均较治疗前有很大改善(P<0.05),并且观察组的Lequesne指数及Womac评分明显较对照组低(P<0.05)。对照组治疗总有效率为73.6%,而观察组治疗总有效率为92.9%,2组比较差异具有统计学意义(P<0.05)。结论:针灸配合补骨健膝方治疗膝骨关节炎疗效确切,其机制可能与降低炎症反应相关。

Objective ： To observe the clinical effect of using acupuncture combined with Bugu Jianxi Recipe in treating wind cold dampness arthralgia type knee osteoarthritis, and to detect the related indexes. Methods： 109 eases of knee osteoarthritis were randomly divided into controlled group and observation group, 53 cases in the controlled group, 56 cases in the observation group, the controlled group was treated with acupuncture treatment, 1 times a day, 15 days for 1 courses, 3 courses of continuous treatment ; the observation group was treated with acupuncture and rehabilitation treatment of knee bone 1,2 times daily, morning and evening meal warm clothes, 15 days for 1 course of treatment, continuous treatment of 3 courses. Detection of 2 groups be- fore and after treatment in the synovial fluid of patients with interleukin 1 beta （ IL-1 beta） , tumor necrosis factor alpha （ TNF-al- pha） and interleukin 6 （IL-6） content, and analyzed and compared hemorheology of the 2 groups of patients after treatment, knee joint function and clinical curative effect. Results： After treatment, the levels of IL-1, TNF-ot and IL-6 in the synovial fluid of the 2 groups were significantly lower than those before treatment （ P 〈 0. 05 ） , and the change degree of the observation group after treatment was significantly higher than that of the controlled group （ P 〈 0. 05 ）. After treatment, 2 groups of patients with knee function scores were significantly improved compared with before treatment （P 〈 0. 05 ）, and Lequesne index and Womac score of the observation group was significantly lower than the controlled group （ P 〈 0. 05 ）. The total effective rate of the controlled group was 73. 6% , while the total effective rate of the observation group was 92. 9% , the difference between the 2 groups was statistically significant （ P 〈 0. 05 ）. Conclusion ： The curative effect of acupuncture combined with rehabilitation for knee joint on the treatment of knee osteoarthritis is exact.