恶性肿瘤高凝状态患者的临床特征

Clinical characteristics of malignant tumor with hypercoagulability

目的:探讨恶性肿瘤高凝状态的临床特点。方法:选取2014年3月至2016年7月就诊于新乡医学院第三附属医院肿瘤科的140例恶性肿瘤患者,根据恶性肿瘤高凝状态的诊断标准将其分为高凝状态组和非高凝状态组。对两组患者的临床资料及凝血指标进行比较与分析。结果:140例恶性肿瘤患者中有62例(44.3%)存在高凝状态。高凝状态组患者PLT、PT、FIB及D-D水平明显高于非高凝状态组,差异均有显著统计学意义(P<0.01),APTT水平比较差异无统计学意义(P>0.05)。高凝状态组患者肺转移、淋巴结转移、肿瘤分期比例显著高于非高凝状态组,差异均有统计学意义(P<0.05),两组患者性别、年龄、肝转移及肿瘤部位比较差异均无统计学意义(P>0.05)。结论:恶性肿瘤患者存在高凝状态,根据其临床特征和凝血功能检测有助于及时发现这种状态,并及时干预可使患者获益。

Objective ： To investigate the clinical characteristics of malignant tumor with hypercoagulability. Meth- ods：The data 140 cases of malignant tumor patients were selected in the Third Affiliated Hospital of Xinxiang Medical University from March 2014 to July 2016. All patients were divided into hypercoagulability group （62 cases） and non - hypercoagulability group （78 cases） according to whether with hypercoagulability or not. The clinical data and co- agulation index were compared between the two groups. Results： 140 cases of patients with malignant tumor in 62 ca- ses （44.3%） had hypercoagulability. The level of PLT,PT,FIB and D -D in hypercoagnlability group were significantlyhigher than non - hypercoagnlability group （P 〈 0.01 ） , there was no significant difference in the level of APTr be- tween the two groups （ P 〉 0.05 ）. The proportion of lung metastasis, lymph node metastasis and tumor stage were sig- nificantly higher in the patients with hypercoagulability group than in the non - hypercoagnlability group （ P 〈 0.05 ）, there was no significant difference in gender, age, liver metastasis and tumor position between the 2 groups （P 〉 0.05）. Conclusion： Hypercoagulability existed in patients with malignant tumors, we must timely discover this state according to the the clinical characteristics and test of coagulation index, and timely intervention measures to make benefits to these patients.