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法莫替丁对布洛芬治疗的老年类风湿性关节炎患者的胃肠道保护作用 被引量:1

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摘要 目的研究结直肠腺癌患者MAPK蛋白磷酸化表达与临床病理及生存率的相关性。方法按随机数表法将210例老年类风湿性关节炎患者均分为治疗组和对照组。对照组给予单一布洛芬治疗,治疗组则给予法莫替丁联合布洛芬用药。记录治疗前后,对照组及治疗组RA评分标准表得分、脱落率、胃肠道不良反应发生率、Lequesne指数评分标准评分以及两组疗效。结果与对照组比较,患者依从性较好,治疗组患者脱落率(0.95%)远低于对照组脱落率(9.52%)。治疗组胃肠道反应阳性率(4.8%)远低于对照组(38.1%),表明法莫替丁能有效降低布洛芬引起的胃肠道损害。但治疗组与对照组疗效并无显著性差异,类风湿性关节炎改善率分别为40.2%及34.2%。另外,治疗组治疗后,能够有效地改善患者关节功能,Lequesne指数评分显示,治疗后治疗组评分从(13.11±2.89)降低至(7.42±1.32),改善幅度大于对照组。结论法莫替丁能够有效地降低布洛芬对老年风湿性关节炎患者的胃肠道刺激,改善患者关节功能,值得推广应用。
作者 林顺权
出处 《牡丹江医学院学报》 2017年第3期66-69,共4页 Journal of Mudanjiang Medical University
基金 惠州市科技计划项目(2016Y233)
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